Spreads picturesquely along a hill ridge, half way along the winding road which links the Metauro Valley (Calcinelli, 13.4 km from Fano) and the Cesano Valley (San Michele al Fiume, 17 km from Marotta).
During the Middle Ages, San Giorgio and the nearby fortified village of Poggio belonged to the Benedictine abbey of San Paterniano in Fano. Later it became part of the vicariate of Mondavio, retaining the right to hold all deeds and public documents regarding the surrounding castles. During the 16^th Century is was given in fief to the Leonelli family, whose members included the jurists Giulio and Malatesta Leonelli and the Blessed Innocenzo Leonelli. The town still retains its original escarpment walls. Inside them stands the parish church of San Giorgio, which perhaps dates back before the 13^th Century but was rebuilt along Neo-classical lines in 1841-2. Inside are several interesting paintings and an early wooden Crucifix. In the borgo beneath the town walls stands the former church of Santo Spirito, built in 1787 and now used as a hall for cultural events. It also contains a number of fine paintings, including "The Descent of the Holy Spirit", dating from the 16^th Century. The 19^th Century church of SS. Crocifisso stands just outside the town on the site of the early church and Carmelite convent of Santa Maria di Castagneto - several of the original building's 15^th and 16^th Century frescoes can still be seen.
The fortified village of Poggio now forms part of the district of San Giorgio. The church and Franciscan monastery of Santa Maria della Misericordia (commonly known as San Pasquale) was founded here in 1523 by the nobleman Mariotto Sajano. The present church was rebuilt in the 20^th Century and holds fine paintings and wooden furnishings, including the magnificent 18^th Century choir stalls from the earlier church.